VIII. How often can I use MDMA?

There is no firm data, as we can't cut open human brains to check serotonin levels. By averaging a number of rat and lower primate studies, Emmanuel Sferios came up with two weeks as being the amount of time it takes for serotonin to replenish itself. Many users have agreed that this "feels right" and for a long time it has been accepted as gospel. However, taking MDMA at this rate over a length of time would result in a "loss of magic" for most users and could result in permanent damage.

Most people agree that using MDMA two nights in a row is a very bad idea. Articles on Erowid seem to indicate that one ought to wait at least a week between doses, and that waiting 4-6 weeks may make more sense. In large part, this is to allowyour body to return to its natural balance. Also, neurotoxicity seems to increase with larger and more frequent doses.