»My sister has been using cocaine & ecstasy at the same time and recently her doctor has put her on Zoloft for depression not knowing of the drug problem. Is this a dangerous combination?
There are no direct physical dangers from mixing Zoloft and Ecstasy (MDMA). Zoloft (or to use its chemical name, Sertraline) is an SSRI (selective serotonin reuptake inhibitors), the same class of anti-depressants as Prozac (Flouxetine), Celexa (Citalopram Hydrobromide), Luvox (Fluvoxamine), and Paxil (Paroxetine). These chemicals will actually reduce or even completely eliminate the effects of Ecstasy when the two are taken together. Also Celexa in particular is sometimes used to treat cocaine-dependency and may reduce cocaine effects and craving.

Cocaine works on the dopamine system in the brain to produce its effects and MDMA has no direct effect on this system, although dopamine does play a role in the MDMA effect. Cocaine, however, does increase heart-rate and blood pressure which may cause physical problems in an unfit person.

Perhaps more importantly, long term, both cocaine and ecstasy cause significant crashes and depression after use. In different ways. There are consistent reports, both anecdotal and scientific, that constant or binge ecstasy use is linked to depressed mood. Cocaine causes noticeable mood-swings and crashes on a next few days basis for occasional users, and long-term mood problems for chronic users